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The U.S. Securities and Exchange Commission has stopped the approval of exchange-traded funds offering more than 2x daily leverage, citing non-compliance with derivatives regulations. This impacts product issuers and signals a stricter stance on complex retail-focused products.
Alnylam Pharmaceuticals (ALNY) will be added to the Nasdaq-100 Index on December 22, 2025. This significant event provides a strong institutional buying catalyst, directly countering recent market concerns about near-term growth headwinds and a lack of late-stage pipeline news.
Palo Alto Investors substantially increased its holding in PTC Therapeutics, acquiring an additional 456,144 shares. The $33.1 million investment elevates PTCT to the fund's second-largest position, signaling strong institutional conviction in the biopharmaceutical company's outlook.